I read both interviews with Brad, and found a couple highlights that were interesting to me:
1) "the main cast of Origins is all-new" - he was very specific, saying "the main cast"... I take this to mean that the main aliens from SCII will not be making an appearance. However, the supporting cast could very well make an appearance in this universe, and this month's Vault update shows that at least the Precursors will be back. But, who else that didn't have a main actor role might be back? The most obvious to me, would possibly be the Dnyarri! He had a supporting role in SCII and I'd love to see that devious little bastard back for more. The Taalo? The Burvixese? Any of the original Sentient Milieu? Gg. Keel-Verezy. Mael-Num. ZEBRANKY?! Also, I feel like it's been very strongly hinted that the Androsynth will play a role, and they were not a "main cast" in SCII. It's even been clearly stated that this universe takes place AFTER the Androsynth rebellion... so they're IN it, clearly. In some form.
2) In the interview, I FINALLY understand why Brad's always making a huge deal about Lip-Syncing! I always thought, whenever it was brought up, what the heck is the big deal? Every game has lip-syncing these days. But, it's actually because "You can literally put in the words and they will say them." It's more for when we make our own stories. When we create a universe, and input all the text, and assign lines to certain aliens - these aliens will ACTUALLY lip-sync all of our input text. That's actually pretty cool, and certainly has never been done, to my knowledge. It'll give that added bonus to make our own stories that much more authentic. I like the idea!
The rest is pretty standard stuff, but I thought those two points were pretty thought-provoking.