My first impression (forgive typos, grammar issues and etc. as i do not have much time to work on this one):
1) The music sample is awesome with subtle references to SC2. Amazing. The best thing I have heard yet out of all SCO soundtrack that devs have presented to us. kudos to Riku.
2) Lore is ok. I would use some other name than the "UN" as this organization is in its decline (at least in our universe :)). Something like Reformed United Nations or League of Nations Reborn (https://en.wikipedia.org/wiki/League_of_Nations) would fit better IMO. I also think that one could add some basic lifeform to one of the Solar System planets (a plant or amoebae or something). To satisfy our search for an alien life. So Sol is still boring but shows that life can be somewhere out there.+ One should be able to encounter some "mining outpost" in the Sol to justify references to development of space industry. Some abandoned mines or research outpost (used to be populated by Synths). I would be a bit careful with using the term singularity as Synths might become godlike in comparison to us humans. Anyways, I would suggest the following idea - when synths "departed or left" - they took most of technologies, know how and etc. and deleted a lot of shit so that humanity was pushed back by several decades and decided to implement laws on limitation of Synths and AI development in order to avoid same developments and confrontation in future. + Synths story might be a separate DLC 
3) origin universe vs. other universes - i am fine with the explanation. Just make sure that SCO universe might have some layers on top and below of it, like "infra" and "supra" (latin) space (aka Quasi space and Orz space or whatever). Like underground or cloud maps in Might and magic or age of wonders. Some space might be used in futre to connect SCO universe to other Universes (mods, conversions). I will call it "thin space"
4) Galaxy and quadrant maps. What can i say... great potential. I would change the colour to a bit (more into blue) and use some "fog" or something (HOMM2 type of map border) to denote unexplored regions. Devs, would you give us some comments on what circles and dots above stars mean. + If circles means spheres f influence - it would still be good to encounter alien vessels beyond their spheres of influence. Btw. what is the maximum number of moons that one planet can have? At the moment I saw just one. And what is the maximum number of planets that on solar system can hold? + Will space station "replace" moons or might orbit moons too?
5) I am happy with Melee Wars outcome. Back to the roots.
6) Ships - I like the ships. It might be interesting to see them in scale comparison (Shofixti vs Ur-Quan dreadnought). I still would like to see some flying saucer or triangle type of UFO ship... may be as a derelict or crash landed game asset with your missing grand-grand-grand father frozen in a cargo pod
. We have to justify alien abductions :)))).
7) Schedule - the game should take as long as it is needed to be a product of high quality. just do not cut some content from the game because you are rushed so that you immediately add it as day 0 DLC (ME 3 Prothean thing.) If you have cost overruns, then you might ask Founders for another round of financing and I am sure that even lifetime founders will be ready to pay extra buck to cover some costs, even if they get nothing extra in return (save for a super quality game)
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I hope this will help.
P.S. I have not commented on August and September updates but i will try to find some time (provided my comments are still of some value to the "outdated" reports). Main concerns - crew shall not be denoted by bars
make it dots or whatever.+ Is it that difficult to make several color schemes for the interface so that some might choose orange, some red, some grey, some blue, some purple? + Plz. work more on backgrounds when one is navigating in the solar system. I am a big fan of pixel graphics so i would prefer pixels to 3d in 80% of cases, but just look at the amazing backgrounds of SC2 (when in a solar system or what one can see in the porthole of Utwig interaction screen). They are not too over saturated with colours (nebulae and etc.), not too empty, just the right mix.