Demigod is geared towards casual.
HoN is geared towards hardcore. HoN's multiplayer client/server seems to be light years better than Demigod's p2p. Gameplay wise, HoN is just like dota.
I also played LoL but I can't comment as the game is under NDA. Since LoL is free, I think LoL should reach 1 million registered users in 1 month like Battlefield Heroes. It took Demigod 1month to sell 100k units so Demigod will only get 1/10th of LoL's community population.
